Activación frontal en sujetos seropositivos asintomáticos al virus de inmunodeficiencia humana durante la discriminación activa entre estímulos

Félix Jesús Amador Romero, Nino Pedro del Castillo Martín

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Resumen

La amplitud y la distribución topográfica del componente P300 fue evaluada en un grupo de seropositivos masculinos al VIH-1 y de seronegativos comparables mientras ejecutaban dos tareas de tiempo de reacción discriminativo de dificultad cognitiva creciente. Los seropositivos mostraron amplitudes consistentemente menores que los controles, una distribución equipotencial del componente a lo largo de la línea media y una mayor activación frontal que se acentuó con el aumento de la dificultad de la tarea. Estos resultados apoyan la hipótesis de que el enlentecimiento cognitivo que caracteriza el Trastorno Cognitivo-Motor asociado al VIH-1 se relaciona con déficit en los sistemas de reclutamiento de centros de procesa-miento y mantenimiento del set atencional necesarios para la ejecución de tareas donde la discriminación entre estímulos y la selección de respuestas es determinante 

Palabras clave

frontalización; seropositivos al VIH-1; P300; enlentecimiento cognitivo; salud ocupacional

Referencias

Ludervold AJ, Karlsen NR, Reinvang I. Assessment of “subcortical dementia” in patients with Huntington´s disease, Parkinson disease, Multiple Sclerosis and AIDS by a neuropsychological screening battery. Scandinavian Journal of Psychology 1994;35:48-55.

Ellis R, Calero P, Stockin,M. HIV Infection and the Central Nervous System: A Primer. Neuropsychol Rev 2009;19:144–51.

Gorman AA, Foley JM, Ettenhofer ML, Hinkin CH, Van Gorp WG. Functional consequences of HIV-associated neuropsychological impairment. Neuropsychol Rev 2009;19:186-203.

Woods SP, Moore DJ, Weber E, Grant I. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 2009;19:152-68.

Van Gor WG, Mitrushina M, Cummnings JL, Satz P, Modesitt J. Normal aging and the subcortical encephalopathy of AIDS. Neuropsychiatry Neuropsychology and Behavioral Neurology 1989;2:5-20

Sánchez Rodríguez JL, Rodríguez Alvarez M. Normal aging and AIDS. Archive Gerontological Geriatric 2003; 36:57-65.

Woods SP, Moore DJ, Weber E, Grant I. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Re. 2009;19: 152-168.

Ances BM, Vaida F, Yeh M., Liang CL., Buxton RB, Letendre S, McCutchan A, Ellis, RJ. The HIV Neurobehavioral Research Center. HIV Infection and aging independently affect brain function as measured by functional magnetic resonance imaging. J Infect Dis 2010;201(3):336-430.

Mayor J, Amador F, Ramírez I. La reserva cognitiva mejora la velocidad de procesamiento de los componentes centrales del TR en adultos mayores pero no en jóvenes. Revista Cubana de Salud y Trabajo 2008;9(1):7-18.

Everall LP; Luthbert PJ. Lantos PL. Neuronal loss in frontal cortex in HIV infection. Lancet 1991; 337:1119-21.

Dunlop O, Bjorklund R, Bruun J, Evensen R, Goplen AK, Liestol K, Sannes M, Maehlen J, Myrvang B. Early psychomotor slowing predicts the development of HIV dementia and autopsy-verified HIV encephalitis. Neuroscience of HIV Infection. Journal of Neurovirology 1998;3-6;4(suppl):348.

Martin A. HIV cognition and the basal ganglia. In: Grant I, Marton A, eds. Neurpsychology of HIV infection. New York: Oxford Univ. Press. ; 1994. p. 234-59.

Band GH, Ridderinkhof KF, Segalowitz S. Explaining neurocognitive aging: Is one factor enough? Brain and Cognition 2002;49:259-67.

West R. In defense of the frontal lobe hypothesis of cognitive aging. J Int Neuropsychol Soc 2000; 6:727-9.

Whelihan WM, Lesher EL. Neuropsychological changes in frontal functions with ageing. Dev Neuropsychol 1985;1:371:80.

Parkin AJ, Java RI. Deterioration of frontal lobe function in normal aging: influences of fluid intelligence versus perceptual speed. Neuropsychology 1999;13:539-45.

Greenwood PM. The frontal aging hypothesis evaluated. J Int Neuropsychol Soc 2000;6:705-526.

Banish MT, Milham MP, Atchley RA, Cohen NJ, Webb A, Wszalek T, Kramer AF, Liang Z, Barad V, Gullett D, Shah Ch, Brown C.

Prefrontal regions play a predominant role in imposing an attentional “set”: evidence from fMRI, Cognitive Brain Research 2000;10:1-9.

Norman DA, Shallice T. Attention and action: Willed and automatic control of behaviour. In: Davison RJ, Schwartz GE, Shapiro, eds. Consciouness and Self-Regulation: Advances in Research and Theory. V. 4, 1:18. New York: Plenum Press; 1986.

Reuter-Lorenz PA, Cappell KA. Neurocognitive aging and the compensation hypothesis. Current Directions in Psychological Science 2008;17(3): 177-82.

Mayor J, Amador F, Ramírez I. La reserva cognitiva mejora la velocidad de procesamiento de los componentes centrales del TR en adultos mayores pero no en jóvenes. Revista Cubana de Salud y Trabajo 2008;9(1):7-18.

Braver TS, Paxton JL, Locke HS, Barch DM. Flexible neural mechanisms of the cognitive control within human prefrontal cortex. PNAS 2009;106(18):7351-6.

Stuss D, Shallice T, Alexander MP, Picton TW. A Multidisciplinary approach to anterior attentional functions. In: Grafman J, Keith, Holyoak J, Boller F, eds. Structure and functions of the human prefrontal cortex. Ann N. Academy Sci 1995;769: 191-211.

Stuss DT, Alexander MP, Floden D, Binns MA, Levine B, McIntosh AR. Fractionation and localization of distinct frontal lobe processes: Evidence from focal lesions in humans. In: Stuss DT, Knight RT, eds. Principles of frontal lobe function. Oxford: Oxford University

Press; 2002. p. 392–407.

Stuss DT, Alexander MP, Shallice T; Picton TW, Binns MA, Macdonald R, Borowieca A, Katzg DI. Multiple frontal systems controlling response speed. Neuropsycholgia 2005;43:396-417.

Amador F. Enlentecimiento cognitivo en el VIH: ¿un signo de envejecimiento cognitivo? Tesis presentada en opción del grado de Doctor en Ciencias de la Salud. La Habana: Instituto Nacional de Salud de los Trabajadores; 2010 (no publicado).

Donchin E, Coles M. Is the P300 component a manifestation of context updating? Behav Brain Sci 1980;11(3):355-425.

Roman R, Brázdil M, Jurák P, Rektor I, Kukleta M. Intracerebral P3-like waveforms and the length of the stimulus-response interval in a visual oddball paradigm. Clinical Neurophysiology 2005;116:160-71.

Dien J, Spencer KM, Donchin E. Parsing the late positive complex: Mental chronometry and the ERP components that inhabit the neighbourhood of the P300. Psychophysiology 2004;41:665-78.

Goodin DS, Aminoff MJ, Chernoff DN, Hollander HA. Long-latency event-related potential in patients infected with human immununodeficiency virus. Ann Neurol 1990;27:414-9.

Arendt G, Hefter H, Nelles HW, Hilperath F, Strohmeyer G. Age-dependent decline in cognitive information processing of HIV-positive individuals detected by event-related potentials. J Neurol Sci 1993;115:223-9.

Baldeweg T, Gruzelier JH, Catalán C, Pughk K, Lovett E, Riccio M, Stygall J, Irving G, Katt S, Hawkins D. Auditory and visual event-related potential in a controlled investigation of HIV infection. EGG Clin Neurophysiol 1993;88:356-68.

Tartar JL, Sheehan CM, Nash AJ, Starratt C, Puga A, Widmayer S. ERPs differ from neurometric tests in assessing HIV-associated cognitive deficit. Neuroreport 2004;15(10):1675-8.

Linville SE, Elliot FS, Larson, GE. Event-related potential as indices of subclinical neurological differences in HIV patients during rapid decision making. J Neuropsych Clin Neurosci 1996;8:293-304.

Jasper HH. The ten-twenty electrode system of the international federation. EEG Clin Neurophysiol 1958;10:371-4.

Amador F, Pelegrina M, Mayor J. Enlentecimiento cognitivo en el trastorno cognitivo-motor asociado al virus de inmunodefi-ciencia humana tipo 1: TR y P300. Actas Esp Psiquiatr 2007;35(4): 221-8.

Amador F, Mayor J, del Castillo N. Enlentecimiento cognitivo en sujetos seropositivos asintomáticos al virus de la inmunodeficiencia humana tipo 1. Rev Neurol 2006;42(3):132-6.

Galán L, Biscay R, Rodríguez JL, Pérez Abalo MC, Rodríguez R. Testing topography differences between event-related brain potentials by using non-parametric combination of permutation test. EEG and Clinical Neurophysiology 1997;102: 240-7.

Johnson R Jr, Donchin E. Second thoughts: Multiple P300s eliciting by a single stimulus. Psychophysiology 1985;22:182-94.

Martin EM, Robertson LC, Edelstein HE, Jagust WJ, Sorensen DJ. Performance of patients with early HIV-1 infection on the Stroop task. J Clin Exper Neuropsychol 1992;14:857-68.

Hinkin CH, Castellon SA, Hardy DJ, Granholm E, Siegle G. Computerized and traditional Stroop task dysfunction in HIV-1 infection. Neuropsychol 1999;13(2):306-16.

Hinkin CH, Castellón SA, Seteven A, Hard DJ. Dual task performance in HIV-1 infection. J Clin Exper Neuropsychol 2000;22(19):16-24.

Takakuwa KM, Calaway E, Naylor H, Herztig KE, Llano LM. The effect of the human inmunodeficiency virus on visual information processing. Biol Psychol 1993;34:194-7.

Sorensen DJ, Martin EM, Robertson LC. Visual attention in HIV infection. Neuropsychology 1994; 8:424-32.

Bashore TR. Age-related changes in mental processing revealed by analyses of event-related brain potentials. In: Rohrbaugh J, Parasuraman R, Johnson R Jr, eds. Event-related brain potentials: Basic issues and applications. New York: Oxford University Press, 1990. p. 242-75.

Knight RT. Contribution of human hippocampal region to novelty detection. Nature 1996;383: 256–9.

Katayama J, Polich J. Stimulus context determines P3a and P3b. Psychophysiology 1998; 35:23–33.

Pfefferbaum A, Ford J, Wenegrad BG, Roth WT, Kopell BS. Clinical application of the P3 component of event-related potentials I. Normal aging, EEG and Clinical Neurophysiology 1984;59:85-103.

Dien J, Spencer KM, Donchin E. Parsing the late positive complex: Mental chronometry and the ERP components that inhabit the neighbourhood of the P300. Psychophysiology 2004;41:665-78.

Dywan J, Segalowitz S, Arsenault A. Electrophysiological response during source memory decision in older and younger adults. Brain & Cognition 2002;49:322-40.

Madden DJ, Langley LK, Denny LL, Turkington TG, Provenzale JM, Hawk TC, Coleman RE. Adult age differences in visual word identification: functional neuroanatomic by positron emission tomography. Brain & Cognition 2002;49: 297-321.

Madden DJ, Gottlob LW, Denny LI, Turkington TG, Provenzale JM, Hawk TC, Coleman RE. Aging and recognition memory: Changes in regional cerebral blood flow associated with components of reaction time distributions. Journal of Cognitive Neuroscience 1999;11-5:511-20.

Milham MP, Erickson KI, Banich .T, Kremer AT, Webb A, Wszalek T, Cohen NJ. Attentional control in the aging brain: insights from an fMRI study of Stroop task. Brain & Cognition 2002;49: 420:35

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